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They may also affect: Insulin sensitivity Fat distribution Muscle mass Appetite and satiety signals Sleep quality Stress response As estrogen declines, the body tends to store more visceral fat even if caloric intake remains the same
The RENAAL trial (N=1,513), which established losartan's renal protective benefit in type 2 diabetic nephropathy, excluded patients on chronic systemic corticosteroids precisely because of confounding renal and metabolic effects [9]
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Their holistic approach takes into account the physical, emotional, and functional aspects of the patients condition, aiming for the best possible long-term outcomes
Creatinine levels may decline alongside reductions in muscle mass, which can complicate kidney marker interpretation over time
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